Agami Reuven
Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam 1066 CX, The Netherlands.
Cell. 2007 Jun 15;129(6):1043-5. doi: 10.1016/j.cell.2007.05.048.
Extensive genetic alterations have been found in many epithelial malignancies. Using three complementary genetic approaches, Boehm et al. (2007) identify IKBKE--which encodes IKKepsilon, a component of the NF-kappaB pathway--as a breast cancer oncogene.
在许多上皮性恶性肿瘤中都发现了广泛的基因改变。Boehm等人(2007年)使用三种互补的基因方法,将编码IKKε(NF-κB途径的一个组成部分)的IKBKE鉴定为一种乳腺癌致癌基因。