Misske J, Männer J, Yelbuz T M
Department of Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
Pediatr Cardiol. 2007 Jul-Aug;28(4):263-6. doi: 10.1007/s00246-006-0109-x. Epub 2007 Jun 19.
The classical Hamburger and Hamilton (HH) paper demonstrates the normal stages of development of the chick embryo that have been extensively used as the basis of understanding normal and abnormal development of the chick embryo heart. Careful examination of the series of images published in this seminal paper indicates that the cardiac images of stage 16 embryo shown in this article may reflect an abnormally developed heart. In this article, the argument is presented that the embryo depicted in the HH paper is not normal, but instead inflicted with a conotruncal heart defect.
经典的汉堡和汉密尔顿(HH)论文展示了鸡胚发育的正常阶段,这些阶段已被广泛用作理解鸡胚心脏正常和异常发育的基础。仔细检查这篇开创性论文中发表的一系列图像表明,本文所示的第16阶段胚胎的心脏图像可能反映了发育异常的心脏。在本文中,有人提出,HH论文中描绘的胚胎并非正常,而是患有圆锥动脉干心脏缺陷。