Upadhyaya Vijay D, Gangopadhyaya A N, Gupta D K, Sharma S P, Kumar Vijayendra, Pandey Anand, Upadhyaya Ashish D
Department of Pediatric Surgery, IMS, BHU, Varanasi 221005, Uttar Pradesh, India.
Pediatr Surg Int. 2007 Aug;23(8):767-71. doi: 10.1007/s00383-007-1964-0. Epub 2007 Jun 20.
Congenital tracheoesophageal fistula (TEF) with esophageal atresia (EA) is not an uncommon disease of newborns. Several classifications have been advocated for predicting the outcomes of these patients but all are physiological and concentrated on associated medical condition that influences survival. We emphasize a new classification on the basis of gap between two esophageal pouches to define the magnitude of surgical problems in the primary repair and correlate them with the outcomes in terms of anastomotic leak, esophageal stricture and mortality, keeping other prognostic factors constant. A total of 50 cases of congenital TEF with EA were included and all underwent primary esophageal anastomosis after the ligation of TEF. The gap between the two pouches was meticulously measured intraoperatively using a vernier caliper before the ligation of TEF, and patients were divided into four groups on the basis of gap length. Group A, where gap length was >3.5 cm (ultralong), group B where gap length was 2.1-3.5 cm (long gap), group C where gap length was >1 cm but not more than 2 cm (intermediate group) and group D, where the gap between two esophageal pouches was 1 cm or less (short gap). The incidence of anastomotic leak was 80, 50, 28, 10.5% and the incidence of esophageal stricture was 100, 75, 22.5, 19% after successful primary repair, respectively, in groups A, B, C and D. The mortality was highest in group A (80%) followed by group B (50%) and 22% in group C and least 15.6% in group D. The incidences of esophageal leak and mortality were found to be statistically significant. This classification which is based on easily measurable criteria provides a useful method to predict morbidity, long-term outcome and mortality of EA with TEF surgery.
先天性食管闭锁(EA)合并气管食管瘘(TEF)是新生儿并不罕见的一种疾病。已经提出了几种分类方法来预测这些患者的预后,但所有分类都是基于生理学的,并且集中在影响生存的相关医学状况上。我们强调基于两个食管盲端之间的间隙进行新的分类,以确定一期修复手术问题的严重程度,并将其与吻合口漏、食管狭窄和死亡率方面的预后相关联,同时保持其他预后因素不变。总共纳入了50例先天性EA合并TEF的病例,所有病例在结扎TEF后均接受了一期食管吻合术。在结扎TEF之前,术中使用游标卡尺仔细测量两个盲端之间的间隙,并根据间隙长度将患者分为四组。A组,间隙长度>3.5 cm(超长间隙);B组,间隙长度为2.1 - 3.5 cm(长间隙);C组,间隙长度>1 cm但不超过2 cm(中间组);D组,两个食管盲端之间的间隙为1 cm或更小(短间隙)。在成功进行一期修复后,A、B、C、D组的吻合口漏发生率分别为80%、50%、28%、10.5%,食管狭窄发生率分别为100%、75%、22.5%、19%。死亡率在A组最高(80%),其次是B组(50%),C组为22%,D组最低为15.6%。食管漏和死亡率的发生率具有统计学意义。这种基于易于测量标准的分类方法为预测EA合并TEF手术的发病率、长期预后和死亡率提供了一种有用的方法。