Hirsch Dania, Narinski Ronit, Klein Tirza, Israel Shoshana, Singer Joelle
Department of Endocrinology, Rabin Medical Center, Beilinson Campus, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hum Immunol. 2007 Jul;68(7):616-22. doi: 10.1016/j.humimm.2007.03.016. Epub 2007 Apr 23.
The distribution of HLA class II alleles and genotypes in Israelis of different ethnic origin with adult-onset type 1 diabetes (T1D) was examined. The results were compared with published findings in healthy Israelis and childhood-onset T1D Israelis. An additional comparison was made between subgroups of patients with rapidly and slowly progressive adult-onset T1D (LADA). A DNA-based low-resolution analysis was performed for DRB1* and DQB1* alleles and a high-resolution analysis for DRB104 and DQB11 alleles. In all, 87% of the study group was positive for DRB103 or DRB104 compared with 36% of the healthy controls. The main alleles accounting for susceptibility to T1D were DRB10402, found in 77.9% of carriers of DRB104 and DQB10302, found in 74.6% of carriers of DQB103. The DQB1*0602 was not detected in any patient. The distribution was similar to that reported in Israeli children with T1D and significantly different from healthy Israelis. There was no significant difference in the distribution of HLA class II alleles between patients with rapidly progressive T1D or LADA. It may be concluded that the different ages of onset of T1D and its different forms of development in Israeli patients are apparently not caused by a different prevalence of HLA class II alleles.
研究了不同种族来源的成年发病型1型糖尿病（T1D）以色列人的HLA II类等位基因和基因型分布。将结果与健康以色列人和儿童发病型T1D以色列人已发表的研究结果进行比较。还对快速进展型和缓慢进展型成年发病型T1D（LADA）患者亚组进行了比较。对DRB1和DQB1等位基因进行了基于DNA的低分辨率分析，对DRB104和DQB11等位基因进行了高分辨率分析。总体而言，研究组中87%的人DRB103或DRB104呈阳性，而健康对照组中这一比例为36%。导致T1D易感性的主要等位基因是DRB10402，在DRB104携带者中占77.9%，DQB10302在DQB103携带者中占74.6%。在任何患者中均未检测到DQB1*0602。该分布与以色列T1D儿童的报道相似，与健康以色列人有显著差异。快速进展型T1D或LADA患者之间HLA II类等位基因分布无显著差异。可以得出结论，以色列患者T1D发病年龄不同及其不同的发展形式显然不是由HLA II类等位基因的不同流行率引起的。
