巨噬细胞源性趋化因子在恶性和结核性胸腔积液中的作用

Macrophage-derived chemokine in malignant and tuberculous pleural effusions.

作者信息

Okamoto Masakazu, Imaizumi Kazuyoshi, Hasegawa Yoshinori, Hashimoto Naozumi, Sumida Atsushi, Shibazaki Masataka, Takagi Kenzo, Shimokata Kaoru, Kawabe Tsutomu

机构信息

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

Respirology. 2007 Jul;12(4):581-4. doi: 10.1111/j.1440-1843.2007.01059.x.

DOI:10.1111/j.1440-1843.2007.01059.x

PMID:17587426

Abstract

BACKGROUND AND OBJECTIVES

Macrophage-derived chemokine (MDC/CCL22) is recognized as a T-helper (Th) 2-type chemokine. Both malignant and tuberculous pleural effusions are typically lymphocytic pleural effusions. Tuberculous pleural effusions have a more polarized Th1 reaction than malignant effusions, which are predominantly Th2 in nature. The aim of this study was to compare the levels of MDC in malignant pleural effusions with those in tuberculous pleural effusions to help delineate the role of MDC in Th2 versus Th1 effusions.

METHODS

Forty-three patients with pleural effusions (32 malignant, 11 tuberculous) were studied. The concentration of MDC in the pleural effusion was measured by ELISA.

RESULTS

The median concentration of MDC was lower in malignant pleural effusions than in tuberculous pleural effusions (P < 0.005).

CONCLUSIONS

MDC has been reported to both promote and suppress antitumour immunity. The low concentration of MDC in malignant effusions is likely to minimise its antitumour activity but the precise role of MDC in malignant and tuberculous effusions needs to be investigated further.

摘要

背景与目的

巨噬细胞源性趋化因子（MDC/CCL22）被认为是一种辅助性T细胞（Th）2型趋化因子。恶性胸腔积液和结核性胸腔积液通常均为淋巴细胞性胸腔积液。结核性胸腔积液比恶性胸腔积液具有更极化的Th1反应，而恶性胸腔积液本质上主要是Th2反应。本研究的目的是比较恶性胸腔积液和结核性胸腔积液中MDC的水平，以帮助阐明MDC在Th2型与Th1型胸腔积液中的作用。