超极化诱导的质子电流是否促成了低钾性周期性麻痹（一种电压传感器通道病）的发病机制？ - Suppr

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超能文献

Do hyperpolarization-induced proton currents contribute to the pathogenesis of hypokalemic periodic paralysis, a voltage sensor channelopathy?

作者信息

Jurkat-Rott Karin, Lehmann-Horn Frank

机构信息

Institute of Applied Physiology, Ulm University, 89069 Ulm, Germany.

出版信息

J Gen Physiol. 2007 Jul;130(1):1-5. doi: 10.1085/jgp.200709834.

DOI:10.1085/jgp.200709834

PMID:17591982

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2154370/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/069c/2154370/6c72ff241430/jgp1300001f01.jpg

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Do hyperpolarization-induced proton currents contribute to the pathogenesis of hypokalemic periodic paralysis, a voltage sensor channelopathy?超极化诱导的质子电流是否促成了低钾性周期性麻痹（一种电压传感器通道病）的发病机制？

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本文引用的文献

J Gen Physiol. 2007 Jul;130(1):11-20. doi: 10.1085/jgp.200709755.

Two atomic constraints unambiguously position the S4 segment relative to S1 and S2 segments in the closed state of Shaker K channel.在Shaker钾通道的关闭状态下，两个原子约束条件明确地确定了S4片段相对于S1和S2片段的位置。

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7904-9. doi: 10.1073/pnas.0702638104. Epub 2007 Apr 30.

Gating pore current in an inherited ion channelopathy.遗传性离子通道病中的门控电流

Nature. 2007 Mar 1;446(7131):76-8. doi: 10.1038/nature05598.

The twisted ion-permeation pathway of a resting voltage-sensing domain.静息电压感应结构域的扭曲离子渗透途径。

Nature. 2007 Feb 1;445(7127):546-9. doi: 10.1038/nature05396. Epub 2006 Dec 24.

Ion permeation through a voltage- sensitive gating pore in brain sodium channels having voltage sensor mutations.离子通过具有电压感受器突变的脑钠通道中的电压敏感门控孔的渗透。

Neuron. 2005 Jul 21;47(2):183-9. doi: 10.1016/j.neuron.2005.06.012.

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus.甲型流感病毒M2离子通道组氨酸选择性过滤器突变体的化学挽救

J Biol Chem. 2005 Jun 3;280(22):21463-72. doi: 10.1074/jbc.M412406200. Epub 2005 Mar 22.

Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores.钾通道中的电压感应精氨酸渗透并阻塞阳离子选择性孔道。

Neuron. 2005 Feb 3;45(3):379-88. doi: 10.1016/j.neuron.2004.12.047.

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Brain. 2002 Apr;125(Pt 4):835-43. doi: 10.1093/brain/awf071.

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