[使用罗斯托克角膜模块HRT II对市售眼科混悬剂进行体外微观结构分析]
[In vitro microstructural analysis of commercial ophthalmic suspensions by HRT II Rostock Cornea Module].
作者信息
Imre L, Resch M, Megyesi M, Németh J
机构信息
Klinik für Augenheilkunde, Semmelweis Universität Budapest, Tömo u.25-29, 1083, Budapest, Ungarn.
出版信息
Ophthalmologe. 2007 Aug;104(8):697-700, 702-4. doi: 10.1007/s00347-007-1549-2.
BACKGROUND
To investigate the particles of commercially used ophthalmic suspensions with the HRT II Rostock Cornea Module and to compare them with particle parameters given in the literature.
METHODS
Software-aided analysis was carried out for the suspensions brinzolamide 1%, betaxolol HCl 0.25%, dexamethasone phosphate 0.1% and prednisolone acetate 0.5%, including measurements of length, area and circumference and calculation of ellipticity and shape factor (SF).
RESULTS
Particle characteristics (SF and ellipticity) of different suspensions demonstrated that the particles are not spherical. Significant aggregation affinity of prednisolone acetate particles was observed.
CONCLUSION
Exact and reproducible in vitro microstructural examination of ophthalmic suspensions was possible due to the high resolution of the HRT II Rostock Cornea Module.
背景
使用HRT II Rostock角膜模块研究市售眼科混悬液的颗粒，并将其与文献中给出的颗粒参数进行比较。
方法
对1%布林佐胺、0.25%盐酸倍他洛尔、0.1%磷酸地塞米松和0.5%醋酸泼尼松龙混悬液进行软件辅助分析，包括长度、面积和周长的测量以及椭圆率和形状因子（SF）的计算。
结果
不同混悬液的颗粒特征（SF和椭圆率）表明颗粒不是球形。观察到醋酸泼尼松龙颗粒有显著的聚集亲和力。
结论
由于HRT II Rostock角膜模块的高分辨率，对眼科混悬液进行精确且可重复的体外微观结构检查是可行的。
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