Wise Lauren A, Titus-Ernstoff Linda, Palmer Julie R, Hoover Robert N, Hatch Elizabeth E, Perez Kimberly M, Strohsnitter William C, Kaufman Raymond, Anderson Diane, Troisi Rebecca
Slone Epidemiology Center, Boston University, Boston, MA 02215, USA.
Am J Epidemiol. 2007 Oct 1;166(7):765-74. doi: 10.1093/aje/kwm136. Epub 2007 Jun 27.
Little is known about the influence of prenatal diethylstilbestrol (DES) exposure on time to pregnancy or secondary sex ratio in men. The authors evaluated these associations among men participating in the DES Combined Cohort Follow-up Study for whom exposure status was confirmed by medical record. In 2001, men provided data on their reproductive histories. Demographic, behavioral, and medical data were collected in 1994, 1997, and 2001. Cox's proportional hazards models with frailty were used to estimate fecundability ratios for time to pregnancy in relation to DES. Generalized estimating equations were used to estimate odds ratios for fathering a male birth in relation to DES. Models included potential confounders and accounted for multiple pregnancies contributed by each man. Overall, DES was not associated with a delay in time to pregnancy (fecundability ratio = 0.95, 95% confidence interval: 0.86, 1.06). The odds ratio for fathering a male birth was 0.92 (95% confidence interval: 0.80, 1.04) comparing the exposed with the unexposed. In conclusion, prenatal DES exposure was not associated with a significant decrease in either fecundability or secondary sex ratio.
关于产前暴露于己烯雌酚（DES）对男性怀孕时间或出生性别比的影响，人们了解甚少。作者在参与DES联合队列随访研究的男性中评估了这些关联，这些男性的暴露状况由医疗记录确认。2001年，男性提供了他们的生殖史数据。1994年、1997年和2001年收集了人口统计学、行为学和医学数据。使用带有脆弱性的Cox比例风险模型来估计与DES相关的怀孕时间的受孕能力比率。使用广义估计方程来估计与DES相关的生育男性后代的优势比。模型纳入了潜在的混杂因素，并考虑了每个男性的多次怀孕情况。总体而言，DES与怀孕时间延迟无关（受孕能力比率=0.95，95%置信区间：0.86，1.06）。将暴露组与未暴露组进行比较，生育男性后代的优势比为0.92（95%置信区间：0.80，1.04）。总之，产前DES暴露与受孕能力或出生性别比的显著降低无关。
