通过串联迈克尔反应快速合成生物素核心。
A rapid synthesis of the biotin core through a tandem Michael reaction.
作者信息
Oh Kyungsoo
机构信息
Department of Chemistry and Chemical Biology, Indiana University Purdue Univeristy Indianapolis, Indianapolis, Indiana 46202, USA.
出版信息
Org Lett. 2007 Aug 2;9(16):2973-5. doi: 10.1021/ol0710663. Epub 2007 Jun 30.
PMID:17602641
Abstract
A biotin core has been assembled in a short and efficient sequence utilizing a tandem intramolecular Michael reaction/fragmentation/Michael reaction from vinyl sulfoxide and sulfone alcohols (12 and 13).
摘要
利用乙烯基亚砜和砜醇（12和13）的串联分子内迈克尔反应/碎片化/迈克尔反应，已以简短而高效的序列组装了一个生物素核心。
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