铜催化二烷基锌和二芳基锌试剂对非环状β-硅基-α,β-不饱和酮的不对称共轭加成反应。高非对映体和对映体纯度烯丙基硅烷的合成。
Cu-catalyzed asymmetric conjugate additions of dialkyl- and diarylzinc reagents to acyclic beta-silyl-alpha,beta-unsaturated ketones. Synthesis of allylsilanes in high diastereo- and enantiomeric purity.
作者信息
Kacprzynski Monica A, Kazane Stephanie A, May Tricia L, Hoveyda Amir H
机构信息
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.
出版信息
Org Lett. 2007 Aug 2;9(16):3187-90. doi: 10.1021/ol071331k. Epub 2007 Jun 30.
A readily available and simple (MW = 444.5 g/mol) valine-based chiral phosphine is used to promote highly efficient catalytic asymmetric conjugate additions of dialkyl- and diarylzinc reagents to acyclic beta-silyl-alpha,beta-unsaturated ketones. The catalytic asymmetric protocol allows access to versatile allylsilanes that bear a trisubstituted olefin in high diastereo- and enantiomeric purity.
一种易于获得且简单的（分子量 = 444.5 g/mol）基于缬氨酸的手性膦被用于促进二烷基锌和二芳基锌试剂对非环状β-硅基-α,β-不饱和酮的高效催化不对称共轭加成反应。该催化不对称方法能够得到具有高非对映体和对映体纯度的带有三取代烯烃的通用烯丙基硅烷。
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