Efficient conversion of tomatidine into neuritogenic pregnane derivative.
作者信息
Matsushita Sayaka, Yanai Yoshihiro, Fusyuku Asami, Fujiwara Yukio, Ikeda Tsuyoshi, Ono Masateru, Han Chunguang, Ojika Makoto, Nohara Toshihiro
机构信息
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan.
出版信息
Chem Pharm Bull (Tokyo). 2007 Jul;55(7):1077-8. doi: 10.1248/cpb.55.1077.
PMID:17603206
Abstract
Moderate acetylation of tomatidine with anhydrous acetic acid and pyridine for 20 h at r.t., followed by pseudomerization in ice-water, gave a delta(20(22))-pseudo compound, which was then subjected to ozonolysis to provide a pregnane derivative in a total 54% yield showing neuritogenic and NGF-enhancing activities.
摘要
Zotero 插件