下咽和喉鳞状细胞癌T4期患者的同步放化疗

Concurrent chemoradiotherapy for T4 patients with hypopharyngeal and laryngeal squamous cell carcinomas.

作者信息

Nishimura Goshi, Tsukuda Mamoru, Horiuchi Choichi, Satake Kenichi, Yoshida Takafumi, Nagao Junichi, Kawakami Mariko, Kondo Norio, Arai Yasuhiro, Taguchi Takahide, Matsuda Hideki, Mikami Yasukazu

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

出版信息

Auris Nasus Larynx. 2007 Dec;34(4):499-504. doi: 10.1016/j.anl.2007.02.004. Epub 2007 Jun 28.

DOI:10.1016/j.anl.2007.02.004

PMID:17604583

Abstract

OBJECTIVES

Concurrent chemoradiotherapy (CCR) was given for the previously untreated T4 hypopharyngeal and laryngeal squamous cell carcinoma patients and the response and survival rates were evaluated.

PATIENTS AND METHODS

A total of 23 patients, namely, 15 for hypopharynx and 8 for larynx were eligible. These patients were given cisplatin and 5-fluorouracil based chemotherapeutic regimens with conventional radiotherapy for a total dose of 66.6-70.2 Gy.

RESULTS

Ten out of the 15 hypopharyngeal carcinoma patients and 4 out of the 8 laryngeal carcinoma patients showed a complete response at the primary sites. The 5-year disease-specific survival rate was 59.4% in all the patients, 51.9% in the hypopharyngeal carcinoma patients, and 71.0% in the laryngeal patients. Seven out of the 12 resectable hypopharyngeal carcinoma patients and 4 out of 8 laryngeal carcinoma patients were able to do without total laryngectomy.

CONCLUSIONS

Based on these results, the survival rate in the hypopharyngeal and laryngeal T4 carcinoma patients treated by CCR seems to be satisfactory and the possibility of organ preservation for the advanced patients is indicated.

摘要