Carreño Mar, Maestro Iratxe, Molins Albert, Donaire Antonio, Falip Merce, Becerra Juan Luis, Castillo Joaquín
Epilepsy Unit, Department of Neurology, Hospital Clínic, c/Villarroel 170, 08036 Barcelona, Spain.
Seizure. 2007 Dec;16(8):709-12. doi: 10.1016/j.seizure.2007.05.011. Epub 2007 Jun 28.
We retrospectively reviewed our clinical experience with PGB when used as add-on therapy in 101 patients (56 women and 45 men) with refractory partial epilepsy, who have been followed up for at least 1 year. Mean age was 40 years (16-64); mean number of concomitant AEDs was 2.8. Most patients (43) had temporal lobe epilepsy. Median number of seizures per month was 16 (3-240). Mean PGB dose used was 412.5 mg. Responder rate (percentage of patients with >or=50% seizure reduction) at 6 and 12 months was 52% and 39.6%, respectively. Seizure freedom for at least 6 and 12 months has been achieved by 12 patients (11.8%) and 6 patients (5.9%) respectively. At 1 year, 61 patients (60.4%) are still taking PGB. Forty patients have discontinued PGB, because of inefficacy (16 patients, 15.8%), adverse effects (15 patients, 14.8%) or both (9 patients, 8.9%). Sixty per cent of patients reported adverse events, being weight gain (>10% body weight) the most frequent, seen in 26 patients (25.7%). Dizziness/ataxia was seen in 20 (19.8%). Adverse effects were generally mild to moderate.
我们回顾性分析了101例难治性部分性癫痫患者（56例女性，45例男性）使用普瑞巴林（PGB）作为附加治疗的临床经验，这些患者均接受了至少1年的随访。平均年龄为40岁（16 - 64岁）；平均联合使用抗癫痫药物（AEDs）的数量为2.8种。大多数患者（43例）患有颞叶癫痫。每月癫痫发作的中位数为16次（3 - 240次）。普瑞巴林的平均使用剂量为412.5毫克。6个月和12个月时的缓解率（癫痫发作减少≥50%的患者百分比）分别为52%和39.6%。分别有12例患者（11.8%）和6例患者（5.9%）实现了至少6个月和12个月的无癫痫发作。1年后，61例患者（60.4%）仍在服用普瑞巴林。40例患者已停用普瑞巴林，原因是无效（16例患者，15.8%）、不良反应（15例患者，14.8%）或两者皆有（9例患者，8.9%）。60%的患者报告了不良事件，体重增加（体重增加>10%）最为常见，26例患者（25.7%）出现此情况。20例患者（19.8%）出现头晕/共济失调。不良反应一般为轻至中度。
