线粒体腺苷酸激酶的抑制剂是否也会影响氧化磷酸化？
Does an inhibitor of mitochondrial adenylate kinase also affect oxidative phosphorylation?
作者信息
Lüstorff J, Schlimme E
出版信息
Experientia. 1976 Mar 15;32(3):298-9. doi: 10.1007/BF01940801.
PMID:176055
Abstract
Adenylate kinase activity of intact mitochondria is strongly inhibited by Ap5A, i.e. p1,p5-Di (adenosine-5') pentaphosphate, whereas oxidative phosphorylation is not affected. Therefore, Ap5A is a useful tool to distinguish between oxidative and non oxidative ATP generating reactions.
摘要
完整线粒体的腺苷酸激酶活性受到Ap5A（即p1,p5-二（腺苷-5'）五磷酸）的强烈抑制，而氧化磷酸化不受影响。因此，Ap5A是区分氧化型和非氧化型ATP生成反应的有用工具。
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