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[韶关地区随机献血人群不规则抗体的筛查分析]

[Screening analysis of irregular antibodies from random donor population in Shaoguan area].

作者信息

Zhu Jian-Ying, Lan Jiong-Cai, Luo Hong-Qing

机构信息

Central Blood Bank of Shaoguan, Shaoguan 512026, China.

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Jun;15(3):630-1.

Abstract

The study was purposed to analyze the frequency and distribution of irregular antibodies in Shaoguan area. Screening 15 033 random donor antibodies in Shaoguan area by screening cells, polybrene and antiglobulin tests. The results indicated that the irregular antibodies were found in 42 samples. The frequency of irregular antibodies in female was higher than that in male (P < 0.001), and Rh blood group antibodies such as anti-D, anti-E, and anti-Ec C were common (47.6%). 2 samples of Le antibodies were failed to be found by polybrene test. 2 samples of irregular antibodies with titer 2 were undiscovered by screening test of 10 pooled samples. In conclusion, because of irregular antibodies resulting in hemolytic transfusion reaction, the investigation of frequency and distribution of irregular antibodies is very important for safe transfusion. Antibody screening must be done for female donors, and especially for massive plasma transfusion of patients with severe and dangerous illness and infants so as to ensure safety.

摘要

本研究旨在分析韶关地区不规则抗体的频率及分布情况。采用筛查细胞、凝聚胺试验和抗球蛋白试验对韶关地区15033例随机供血者抗体进行筛查。结果显示,42份样本中发现不规则抗体。女性不规则抗体频率高于男性(P<0.001),常见的Rh血型抗体如抗-D、抗-E和抗-Ec C等占47.6%。凝聚胺试验未检出2份Le抗体样本。10份混合样本筛查试验未发现2份效价为2的不规则抗体样本。总之,由于不规则抗体可导致溶血性输血反应,因此调查不规则抗体的频率及分布情况对安全输血非常重要。对于女性献血者,尤其是对重症危症患者及婴儿进行大量血浆输注时,必须进行抗体筛查以确保安全。

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