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卡介苗膀胱内治疗后继发牛分枝杆菌的破裂性霉菌性腹主动脉瘤

Ruptured mycotic abdominal aortic aneurysm secondary to Mycobacterium bovis after intravesical treatment with bacillus Calmette-Guérin.

作者信息

Harding Gregory E J, Lawlor D Kirk

机构信息

Division of Vascular Surgery, London Health Sciences Centre and University of Western Ontario, 800 Commissioners Road E., London, Ontario, Canada.

出版信息

J Vasc Surg. 2007 Jul;46(1):131-4. doi: 10.1016/j.jvs.2007.01.054.

Abstract

Bacillus Calmette-Guérin (BCG) is a live attenuated strain of Mycobacterium bovis that has proven effective in the treatment of early-stage bladder cancer. Although intravesical therapy with BCG is generally considered safe, serious complications including hematuria, granulomatous pneumonitis, hepatitis, and life-threatening BCG sepsis are well known. BCG-related vascular infections are rarely reported. We present a case of a ruptured abdominal aortic aneurysm secondary to M bovis infection 2 years after intravesical instillation of BCG and review the related literature.

摘要

卡介苗(BCG)是一种减毒活牛分枝杆菌菌株,已被证明对早期膀胱癌的治疗有效。尽管膀胱内灌注卡介苗治疗通常被认为是安全的,但包括血尿、肉芽肿性肺炎、肝炎以及危及生命的卡介苗败血症等严重并发症却是众所周知的。卡介苗相关的血管感染很少有报道。我们报告一例在膀胱内灌注卡介苗两年后发生牛分枝杆菌感染继发腹主动脉瘤破裂的病例,并复习相关文献。

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