阻力训练对大鼠模型心室功能和肥大的影响。
Effects of resistance training on ventricular function and hypertrophy in a rat model.
作者信息
Barauna Valério Garrone, Rosa Kaleizu Teodoro, Irigoyen Maria Cláudia, de Oliveira Edilamar Menezes
机构信息
School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
出版信息
Clin Med Res. 2007 Jun;5(2):114-20. doi: 10.3121/cmr.2007.707.
OBJECTIVE
The purpose of this study was to follow the ventricular function and cardiac hypertrophy in rats undergoing a resistance-training program for a period of 3 months.
DESIGN
Forty animals were divided into two major groups: control (n=16) and resistance trained (n=24). From the resistance-trained group, 12 animals were resistance trained for 1 month and another 12 for 3 months. The resistance-training protocol was performed with 4 sets of 12 repetitions using 65% to 75% of one repetition maximum (maximum lifted weight with the exercise apparatus).
METHODS
Echocardiographic analysis was performed at the beginning of the resistance-training period and at the end of each month. The repetition maximum was measured every 2 weeks. Cardiac hypertrophy was determined by echocardiography, by the absolute weight of the cardiac chambers and by histology of the left ventricle.
RESULTS
Before resistance training, both groups had similar repetition maximums, ranging from 1.8-fold to 2-fold the body weight; however, at the end of the resistance-training period, the repetition maximum of the resistance-trained group was 6-fold greater than the body weight. The left ventricular mass as assessed by echocardiography was 8%, 12% and 16% larger in the resistance-trained group than in the control group in the first, second and third months, respectively. This hypertrophy showed a similar increase in the interventricular septum and in the free posterior wall mass. There was no reduction in the end-diastolic left ventricular internal diameter during the 3-month resistance-training period. Systolic function did not differ between the groups throughout the resistance-training period.
CONCLUSION
Resistance training induces the development of concentric cardiac hypertrophy without ventricular dysfunction or cavity reduction. Although diastolic function was not completely investigated, we cannot exclude the possibility that resistance training results in diastolic dysfunction.
目的
本研究旨在追踪大鼠进行为期3个月的抗阻训练计划期间的心室功能和心脏肥大情况。
设计
40只动物被分为两大组：对照组（n = 16）和抗阻训练组（n = 24）。在抗阻训练组中，12只动物进行1个月的抗阻训练，另外12只进行3个月的抗阻训练。抗阻训练方案为每组12次重复，共4组，使用1次最大重复量（使用训练器械能举起的最大重量）的65%至75%。
方法
在抗阻训练期开始时及每个月末进行超声心动图分析。每2周测量1次1次最大重复量。通过超声心动图、心腔绝对重量和左心室组织学检查来确定心脏肥大情况。
结果
在抗阻训练前，两组的1次最大重复量相似，为体重的1.8倍至2倍；然而，在抗阻训练期结束时，抗阻训练组的1次最大重复量比体重高6倍。通过超声心动图评估，抗阻训练组在第1、第2和第3个月的左心室质量分别比对照组大8%、12%和16%。这种肥大在室间隔和左心室后壁质量上呈现出相似的增加。在3个月的抗阻训练期内，左心室舒张末期内径没有减小。在整个抗阻训练期内，两组的收缩功能没有差异。
结论
抗阻训练可诱导向心性心脏肥大的发展，而不伴有心室功能障碍或腔径减小。尽管舒张功能未得到全面研究，但我们不能排除抗阻训练导致舒张功能障碍的可能性。
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