Quinlan P E, Alessi N E
Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor 48109-0290.
Brain Res Dev Brain Res. 1991 Sep 19;62(1):1-5. doi: 10.1016/0165-3806(91)90183-j.
A comparison was made of beta-endorphin (B-END) concentrations versus post-translation products during the perinatal period in the hypothalamus and the caudal medulla oblongata. The concentration of B-END-like immunoreactivity did not differ statistically between embryonic day 21 (E21) and postnatal day 1 (P1) in either area. There were significant differences in forms, with a shift from larger precursors at E21 to smaller peptides at P1, with the predominant form of B-END being the 31 residue form at E21 in both regions. B-END varied between the two regions at P1, the 27-26 residue predominant in the hypothalamus, and the 31 residue in the caudal medulla.
对围产期下丘脑和延髓尾部中β-内啡肽（B-END）浓度与翻译后产物进行了比较。在这两个区域中，胚胎第21天（E21）和出生后第1天（P1）的B-END样免疫反应性浓度在统计学上没有差异。在形式上存在显著差异，从E21时较大的前体转变为P1时较小的肽，在两个区域中E21时B-END的主要形式均为31个残基的形式。在P1时，两个区域的B-END有所不同，下丘脑以27-26个残基为主，延髓尾部以31个残基为主。
