卡他莫拉菌临床分离株的药敏模式及BROβ-内酰胺酶类型评估
Evaluation of susceptibility patterns and BRO beta-lactamase types among clinical isolates of Moraxella catarrhalis.
作者信息
Esel D, Ay-Altintop Y, Yagmur G, Gokahmetoglu S, Sumerkan B
机构信息
Department of Microbiology and Clinical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey.
出版信息
Clin Microbiol Infect. 2007 Oct;13(10):1023-5. doi: 10.1111/j.1469-0691.2007.01776.x. Epub 2007 Jul 3.
The aims of this study were to detect BRO beta-lactamase types and to evaluate any correlation with the susceptibility patterns of 90 clinical isolates of Moraxella catarrhalis. The overall prevalences of the bro-1 and bro-2 genes were 78% and 12%, respectively. Penicillin G MICs for BRO-1+ isolates were significantly higher than those for BRO-2+ isolates. All the isolates were susceptible to amoxycillin-clavulanate, levofloxacin and cefixime. Resistance to clarithromycin, tetracycline and trimethoprim-sulphamethoxazole was 1.1%, 2.2% and 1.1%, respectively. One-step, length-based PCR was an efficient method to screen for BRO beta-lactamase genes.
本研究的目的是检测卡他莫拉菌BROβ-内酰胺酶类型，并评估其与90株临床分离株药敏模式的相关性。bro-1和bro-2基因的总体流行率分别为78%和12%。BRO-1+分离株的青霉素G最低抑菌浓度显著高于BRO-2+分离株。所有分离株对阿莫西林-克拉维酸、左氧氟沙星和头孢克肟敏感。对克拉霉素、四环素和甲氧苄啶-磺胺甲恶唑的耐药率分别为1.1%、2.2%和1.1%。一步法基于长度的PCR是筛选BROβ-内酰胺酶基因的有效方法。
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