Chen Christopher S
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dev Cell. 2007 Jul;13(1):9-10. doi: 10.1016/j.devcel.2007.06.007.
The Rho family GTPases regulate many cellular functions including the organization, mechanics, and dynamics of the actin cytoskeleton. Re-engineering the highly conserved autoinhibitory structure of GEFs, Yeh et al. (2007) generated novel synthetic proteins that regulated Rho GTPase signaling and cell morphology, highlighting the power of protein module engineering.
Rho家族GTP酶调节许多细胞功能，包括肌动蛋白细胞骨架的组织、力学和动力学。Yeh等人（2007年）通过重新设计鸟嘌呤核苷酸交换因子（GEF）高度保守的自抑制结构，生成了调节Rho GTP酶信号传导和细胞形态的新型合成蛋白，突出了蛋白质模块工程的强大作用。
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