Aghamohammadi Asghar, Rezaei Nima, Gharagozlou Mohammad, Ramyar Asghar, Mahjoub Fatemeh, Rezaei-Kalantari Kiara, Moin Mostafa
Department of Allergy and Clinical Immunology of Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Pediatr Hematol Oncol. 2007 Jul-Aug;24(5):337-42. doi: 10.1080/08880010701369982.
Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by decreased serum immunoglobulin levels, and increased susceptibility to recurrent bacterial infections, malignancies, and autoimmune disorders. In this report, 2 siblings with CVID who developed Hodgkin lymphoma are presented: a 16-year-old girl at stage IIB and her 12-year-old brother at stage IIIB of Hodgkin lymphoma. Their father and 1 uncle were also affected by the same cancer with no immunodeficiency state. The presence of lymphoma should be considered in the patients with CVID, especially in those with family history of malignancies.
普通可变免疫缺陷（CVID）是一组异质性疾病，其特征为血清免疫球蛋白水平降低，以及对复发性细菌感染、恶性肿瘤和自身免疫性疾病的易感性增加。在本报告中，介绍了2例患有CVID并发生霍奇金淋巴瘤的同胞：一名16岁处于IIB期的女孩和她12岁处于IIIB期的弟弟。他们的父亲和1名叔叔也患有同样的癌症，但无免疫缺陷状态。CVID患者应考虑淋巴瘤的存在，尤其是那些有恶性肿瘤家族史的患者。
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