Hsu David A, Stafstrom Carl E, Rowley Howard A, Kiff Jane E, Dulli Douglas A
Department of Neurology H6/526, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.
Brain Dev. 2008 Jan;30(1):86-90. doi: 10.1016/j.braindev.2007.05.013. Epub 2007 Jul 5.
A 20-year-old female with hemiplegic migraine was treated during an acute attack with intravenous verapamil, which reproducibly resolved the headache within 20 min but did not affect her hemiplegia. Magnetic resonance (MR) and computed tomographic (CT) angiography and perfusion performed during the attack showed vasodilation and hyperperfusion. Cerebral hyperperfusion concurrent with hemiplegia suggests a dissociation between cerebral perfusion and neuronal function in hemiplegic migraine. The beneficial effect of verapamil on headache but not hemiplegia suggests a distinct mechanism for pain and neuronal dysfunction in hemiplegic migraine, with the beneficial effect on pain not due to vasodilation.
一名20岁偏瘫性偏头痛女性在急性发作期间接受了静脉注射维拉帕米治疗，该治疗可在20分钟内反复缓解头痛，但对其偏瘫症状无影响。发作期间进行的磁共振（MR）和计算机断层扫描（CT）血管造影及灌注检查显示血管扩张和血流灌注增加。偏瘫同时出现脑血流灌注增加提示偏瘫性偏头痛时脑灌注与神经元功能之间存在分离。维拉帕米对头痛有效但对偏瘫无效，这表明偏瘫性偏头痛中疼痛和神经元功能障碍存在不同机制，对疼痛的有益作用并非由于血管扩张。
