用于铱催化亚胺不对称氢化反应的新型含磷、氮二茂铁基配体。

New P,N-ferrocenyl ligands for the asymmetric Ir-catalyzed hydrogenation of imines.

作者信息

Cheemala Murthy N, Knochel Paul

机构信息

Department Chemie und Biochemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377 München, Germany.

出版信息

Org Lett. 2007 Aug 2;9(16):3089-92. doi: 10.1021/ol071168t. Epub 2007 Jul 7.

DOI:10.1021/ol071168t

PMID:17616202

Abstract

The Ir-catalyzed enantioselective hydrogenation of various N-(3,5-dimethyl-4-methoxy)phenylimines was performed under mild conditions in the presence of new P,N-ferrocenyl iridium complexes leading to (R)-N-(3,5-dimethyl-4-methoxy)phenylamines in high yields and enantioselectivities (up to 99%). These chiral aryl amines can be readily deprotected using Ce(NH4)2(NO3)6.

摘要

在温和条件下，以新型P,N-二茂铁基铱配合物为催化剂，对各种N-(3,5-二甲基-4-甲氧基)苯基亚胺进行铱催化的对映选择性氢化反应，以高产率和对映选择性（高达99%）得到(R)-N-(3,5-二甲基-4-甲氧基)苯胺。这些手性芳基胺可以很容易地用硝酸铈铵脱保护。