Thielke James, Kaplan Bruce, Benedetti Enrico
Department of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Semin Nephrol. 2007 Jul;27(4):408-13. doi: 10.1016/j.semnephrol.2007.03.003.
In the past, ABO incompatibility has been considered an absolute contraindication for living donor kidney transplantation. Over the past 25 years, advances in immunosuppressive therapy and progressively more refined desensitization protocols have allowed increasingly successful transplantations across the ABO barrier. Current results of kidney transplants from ABO-incompatible living donors are quite favorable and comparable in the long term with the outcome of ABO-compatible organs both in Japan and in the United States. The present article reviews the history, outcomes, and current issues in kidney transplantation with ABO-incompatible living donors in adult and pediatric recipients.
过去，ABO血型不相容一直被视为活体供肾移植的绝对禁忌证。在过去25年中，免疫抑制治疗的进展以及日益精细的脱敏方案使得跨越ABO血型屏障的移植越来越成功。目前，来自ABO血型不相容活体供者的肾移植结果相当良好，从长期来看，在日本和美国，其结果与ABO血型相容器官的移植结果相当。本文综述了成人和儿童受者接受ABO血型不相容活体供者肾移植的历史、结果及当前问题。
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