Shepherd M E, Raimer S S, Tyring S K, Smith E B
Department of Dermatology, University of Texas Medical Branch, Galveston 77550.
J Am Acad Dermatol. 1991 Nov;25(5 Pt 2):925-8. doi: 10.1016/0190-9622(91)70285-a.
The glucagonoma syndrome is characterized by elevated serum glucagon, a pancreatic alpha-cell tumor, anemia, hypoaminoacidemia, and necrolytic migratory erythema. Necrolytic migratory erythema may cause marked morbidity and is frequently misdiagnosed. A 42-year-old white woman with a 1 1/2-year history of refractory dermatitis (most severe on the lower extremities) had the glucagonoma syndrome. Her severe morbidity was markedly relieved with the administration of intravenous amino acids. This therapy was successful in controlling the necrolytic migratory erythema through recurrences after somatostatin (SMS 201-995), surgical debulking, and chemotherapy proved inadequate.
胰高血糖素瘤综合征的特征为血清胰高血糖素升高、胰腺α细胞瘤、贫血、低氨基酸血症和坏死性游走性红斑。坏死性游走性红斑可导致明显的发病率，且常被误诊。一名42岁的白人女性，有1年半的难治性皮炎病史（最严重的部位在下肢），患有胰高血糖素瘤综合征。静脉输注氨基酸后，她的严重病情明显缓解。在生长抑素（SMS 201-995）、手术减瘤和化疗均被证明无效后，这种疗法成功地控制了坏死性游走性红斑的复发。
