克拉霉素诱发尖端扭转型室性心动过速。
Clarithromycin induced torsade de pointes.
作者信息
Hensey C, Keane D
机构信息
Department of Cardiology, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
出版信息
Ir J Med Sci. 2008 Mar;177(1):67-8. doi: 10.1007/s11845-007-0057-3. Epub 2007 Jul 7.
BACKGROUND
Clarithromycin is a commonly used macrolide antibiotic. It is known to cause QT prolongation. Medication induced QT prolongation is a major risk factor for the development of torsade de pointes.
METHODS
A 79-year-old lady presented with frequent episodes of torsade de pointes following commencement of clarithromycin. This was noted to be in association with a prolongation of the QT interval.
CONCLUSION
Knowledge of medications which prolong the QT interval is important to minimize the risk of ventricular arrhythmias, which may lead to sudden death. This is essential in patients with a congenitally long QT interval.
背景
克拉霉素是一种常用的大环内酯类抗生素。已知其会导致QT间期延长。药物诱导的QT间期延长是尖端扭转型室速发生的主要危险因素。
方法
一名79岁女性在开始使用克拉霉素后出现频繁的尖端扭转型室速发作。发现这与QT间期延长有关。
结论
了解可延长QT间期的药物对于将可能导致猝死的室性心律失常风险降至最低很重要。这对于先天性QT间期延长的患者至关重要。
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