PDZ结构域：折叠与结合

PDZ domains: folding and binding.

作者信息

Jemth Per, Gianni Stefano

机构信息

Department of Medical Biochemistry and Microbiology, Uppsala University, BMC Box 582, SE-75123 Uppsala, Sweden.

出版信息

Biochemistry. 2007 Jul 31;46(30):8701-8. doi: 10.1021/bi7008618. Epub 2007 Jul 10.

DOI:10.1021/bi7008618

PMID:17620015

Abstract

The PDZ domain is one of the most common protein-protein interaction domains in humans, and it is found in all kingdoms of life. We will review recent progress in the understanding of biophysical aspects of PDZ domains with emphasis on the folding and binding reactions. Finally, we discuss an intriguing correlation between stability and binding of peptide for PDZ2 from PTP-BL.

摘要

PDZ结构域是人类中最常见的蛋白质-蛋白质相互作用结构域之一，并且在所有生命王国中都能找到。我们将回顾在理解PDZ结构域生物物理方面的最新进展，重点是折叠和结合反应。最后，我们讨论了来自PTP-BL的PDZ2在肽的稳定性和结合之间的一种有趣的相关性。