Parvizi Javad, Smith Eric B, Pulido Luis, Mamelak Josh, Morrison William B, Purtill James J, Rothman Richard H
Rothman Institute of Orthopedics, Thomas Jefferson Hospital, 925 Chestnut Street, Philadelphia, PA 19107, USA.
Clin Orthop Relat Res. 2007 Oct;463:107-13. doi: 10.1097/BLO.0b013e318145af41.
In recent years, there has been an apparent increase in the incidence of pulmonary embolus after joint arthroplasty at our institution. We hypothesized the use of sophisticated imaging modalities such as the multidetector computed tomography scan, with better sensitivity, resulted in an apparent increase in the incidence of pulmonary embolus. We studied all patients with pulmonary embolus after joint arthroplasty between 2000 and 2005. The incidence of pulmonary embolus increased from 0.21% (six of 2859) when VQ scan was the modality of choice to 0.98% (50 of 5095) during the time spiral computed tomography was used to 1.72% (89 of 5179) in recent years when multidetector computed tomography was used. Despite the apparent increase in pulmonary embolus, we observed no change in mortality during the study period. Surgeons should be aware of the challenges sophisticated imaging modalities in general and modern imaging introduce for pulmonary embolus in particular. Extremely sensitive imaging tests with unknown specificity have resulted in an increase in diagnosed pulmonary embolus. However, diagnosing pulmonary embolus generates implications for further treatment such as prolonged anticoagulation and/or inferior vena cava filter insertion with potential for catastrophic complications. The challenge is to distinguish which require treatment and which do not.
近年来,在我们机构,关节置换术后肺栓塞的发生率明显上升。我们推测,诸如多排螺旋计算机断层扫描等具有更高灵敏度的先进成像方式导致了肺栓塞发生率的明显上升。我们研究了2000年至2005年间所有关节置换术后发生肺栓塞的患者。肺栓塞的发生率从通气灌注扫描作为首选检查方式时的0.21%(2859例中有6例),上升至螺旋计算机断层扫描应用期间的0.98%(5095例中有50例),到近年来使用多排螺旋计算机断层扫描时的1.72%(5179例中有89例)。尽管肺栓塞发生率明显上升,但我们观察到研究期间死亡率并无变化。外科医生应意识到,一般而言先进成像方式,尤其是现代成像技术给肺栓塞诊断带来的挑战。特异性未知的高灵敏度成像检查导致了肺栓塞诊断病例的增加。然而,肺栓塞的诊断对进一步治疗有影响,比如延长抗凝治疗和/或植入下腔静脉滤器,这可能引发灾难性并发症。挑战在于区分哪些需要治疗,哪些不需要治疗。