氯硝西泮对伴有中央颞区脑电图病灶的儿童良性癫痫罗兰放电的影响。

The effects of clonazepam on rolandic discharge of benign epilepsy of children with centro-temporal EEG foci.

Takahashi K, Saito M, Kyo K, Gomibuchi K, Niijima S, Tada H, Honda T, Sato Y, Takahashi H, Ohtsuka C

Department of Pediatrics, Juntendo University, Tokyo, Japan.

Jpn J Psychiatry Neurol. 1991 Jun;45(2):468-70. doi: 10.1111/j.1440-1819.1991.tb02523.x.

Abstract

CZP had marked effects on RD. RD disappeared in 8 (73%) of 11 patients treated with CZP alone and 6 (43%) of 14 treated with CZP in combination with other drugs. Even when RD persisted, its amplitude and frequency decreased in some patients. 2) In the group treated with CZP in combination with other drugs, RD disappeared in all 5 patients with the persistent RD, of whom 2 had arachnoid cyst. Of the 6 patients with frequent seizures, 2 were subsequently diagnosed as having CPS and SPS, respectively. Patients who did not respond to CPZ included those in whom the diagnosis of BECCT should be reconfirmed, and electro-clinical response may be also useful for diagnosing RD. 3) In patients treated with CZP alone for a short-term treatment of BECCT, the drug administration could be discontinued only in one. A longer follow-up study is necessary to reach a conclusion in future.

摘要

氯硝西泮（CZP）对 Rolandic 区放电（RD）有显著效果。在 11 例仅接受 CZP 治疗的患者中，8 例（73%）的 RD 消失；在 14 例接受 CZP 联合其他药物治疗的患者中，6 例（43%）的 RD 消失。即使 RD 持续存在，部分患者其波幅和频率也有所下降。2) 在接受 CZP 联合其他药物治疗的组中，所有 5 例持续存在 RD 的患者（其中 2 例有蛛网膜囊肿）的 RD 均消失。在 6 例频繁发作的患者中，2 例随后分别被诊断为中央颞区癫痫（CPS）和睡眠相关癫痫性电持续状态（SPS）。对氯氮平（CPZ）无反应的患者包括那些需要重新确认是否为伴中央颞区棘波的儿童良性癫痫（BECCT）的患者，并且电-临床反应可能对诊断 RD 也有用。3) 在仅接受 CZP 短期治疗 BECCT 的患者中，仅 1 例患者可以停药。未来需要进行更长时间的随访研究才能得出结论。