脑脊液生物标志物可预测健康老年人3年内主观认知功能的下降。
Cerebrospinal fluid biomarkers predict decline in subjective cognitive function over 3 years in healthy elderly.
作者信息
Stomrud Erik, Hansson Oskar, Blennow Kaj, Minthon Lennart, Londos Elisabet
机构信息
Clinical Memory Research Unit, Department of Clinical Sciences Malmo, Lund University, University Hospital MAS, Malmo, Sweden.
出版信息
Dement Geriatr Cogn Disord. 2007;24(2):118-24. doi: 10.1159/000105017. Epub 2007 Jul 2.
OBJECTIVE
To investigate whether cerebrospinal fluid (CSF) biomarkers can predict cognitive decline in healthy, elderly individuals as they have been shown to do in cognitively impaired patient samples.
METHODS
In this study, 57 controls were tested for CSF biomarkers at baseline and then cognitively followed over 3 years.
RESULTS
Low levels of baseline beta-amyloid 1-42 (Abeta42) were associated with development of subjective memory impairment affecting quality of life (memQoL), with a worse Mini Mental Status Examination score and with inability to live in regular housing at follow-up (p < 0.05). The combination of baseline Abeta42 and phosphorylated tau (P-tau) was found to predict development of pathological memQoL with a sensitivity of 71.4% and a specificity of 75.7 (<0.01).
CONCLUSION
Low Abeta42 and combined Abeta42 and P-tau predicted subjective cognitive decline in healthy individuals. In summary, this study shows that already in the clinically normal population Alzheimer-disease-related biological signs might be detectable.
目的
研究脑脊液（CSF）生物标志物是否能像在认知受损患者样本中那样，预测健康老年人的认知衰退。
方法
在本研究中，57名对照者在基线时接受了脑脊液生物标志物检测，随后进行了3年的认知随访。
结果
基线β-淀粉样蛋白1-42（Aβ42）水平较低与影响生活质量的主观记忆障碍（memQoL）的发展、简易精神状态检查得分较低以及随访时无法居住在普通住房中有关（p<0.05）。发现基线Aβ42和磷酸化tau蛋白（P-tau）的组合可预测病理性memQoL的发展，敏感性为71.4%，特异性为75.7（<0.01）。
结论
低Aβ42以及Aβ42与P-tau的组合可预测健康个体的主观认知衰退。总之，本研究表明，在临床正常人群中，已经可以检测到与阿尔茨海默病相关的生物学迹象。
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