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[波兰儿童的艾滋病毒感染——诊断时的临床进展]

[HIV infection in children in Poland - clinical advancement at time of diagnosis].

作者信息

Dobosz Sabina, Marczyńska Magdalena, Szczepańska-Putz Małgorzata, Popielska Jolanta, Ołdakowska Agnieszka

机构信息

Klinika Chorób Zakaźnych Wieku Dzieciecego, Akademia Medyczna, ul. Wolska 37, 01-201 Warszawa, Poland.

出版信息

Med Wieku Rozwoj. 2007 Apr-Jun;11(2 Pt 1):167-71.

Abstract

UNLABELLED

At the end of 2006, there were about 130 children with confirmed HIV infection in Poland, 90% of them being infected vertically.

AIM

to present the causes, the diagnostic procedure of HIV infection and the assessment of clinical staging at diagnosis of vertical infection in a child.

MATERIALS AND METHODS

between 1987-2006 there were 86 HIV infected children (45 male, 41 female) treated in our Department. 78 children had been infected vertically, 8 by other route. Reasons for HIV testing in children and clinical staging at diagnosis were analysed in vertically infected children. The patients were divided into two groups: I - diagnosed because of clinical signs and symptoms, II - because of knowledge of HIV positive status in family members.

RESULTS

there were 22/79 children in group I and 56/79 in group II. Vertical HIV infection diagnosis was confirmed at the age from 1 month to 11 years, the mean age was: 26 months - in group I, 25 months - in group II. During the first year of life HIV infection was diagnosed in 36 children (33% of them having AIDS, 36% severe immunodeficiency), at the age of 12-35 months in 22 children (23% of them having AIDS, 32% severe immunodeficiency) and above 35 months in 20 children (15% of them having AIDS, 35% severe immunodeficiency), respectively. Children diagnosed because of clinical manifestations were more likely to have AIDS (p<0.01) and severe immunodeficiency (p<0.07).

CONCLUSIONS

early diagnosis in children relies on the knowledge on the mother's HIV infection positive status. In Poland vertical HIV infection diagnosis is established late (mean: above 2 years), often at the advanced stage of the disease.

摘要

未标注

2006年底,波兰约有130名儿童确诊感染艾滋病毒,其中90%为垂直感染。

目的

介绍儿童垂直感染艾滋病毒的病因、诊断程序以及诊断时的临床分期评估。

材料与方法

1987年至2006年期间,我科共治疗了86名感染艾滋病毒的儿童(45名男性,41名女性)。78名儿童为垂直感染,8名通过其他途径感染。分析了垂直感染儿童进行艾滋病毒检测的原因以及诊断时的临床分期。将患者分为两组:第一组——因临床症状和体征确诊;第二组——因家庭成员艾滋病毒检测呈阳性确诊。

结果

第一组有22/79名儿童,第二组有56/79名儿童。垂直感染艾滋病毒的诊断年龄为1个月至11岁,平均年龄为:第一组26个月,第二组25个月。一岁以内诊断出艾滋病毒感染的儿童有36名(其中33%患有艾滋病,36%有严重免疫缺陷),12至35个月大的儿童有22名(其中23%患有艾滋病,32%有严重免疫缺陷),35个月以上的儿童有20名(其中15%患有艾滋病,35%有严重免疫缺陷)。因临床表现确诊的儿童更易患艾滋病(p<0.01)和严重免疫缺陷(p<0.07)。

结论

儿童早期诊断依赖于对母亲艾滋病毒感染阳性状况的了解。在波兰,垂直感染艾滋病毒的诊断较晚(平均:2岁以上),且往往处于疾病晚期。

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