[功能性下颌前伸过程中幼鼠髁突软骨中明胶酶表达的变化]
[Changes in expression of gelatinase in young rat condylar cartilage during functional mandibular advancement].
作者信息
Wang Yan-Min, Wang Sheng-Guo, Zhou Li, Chen Yang-Xi
机构信息
Key Laboratory of Oral Biomedical Engineering of Ministry of Education, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2007 Jun;25(3):299-301, 305.
OBJECTIVE
To investigate the changes in expression of gelatinase (MMP-2, MMP-9) in young rat condylar cartilage during functional mandibular advancement.
METHODS
Sixty male 5-week old SD rats were divided into experimental and control groups. The mimic functional appliances were used in experimental group rats. The animals were sacrificed after 1, 2, 4 weeks. The immunoreactivity of gelatinase was detected by immunohistochemistry.
RESULTS
In normal mandibular condylar cartilage, the immunoreactivity of MMP-2 was rather strong, the immunoreactivity of MMP-9 was very weak. Following functional mandibular advancement, the expression of MMP-9 was significantly increased (P < 0.01), but immunoreactivity of MMP-2 had no significant changes.
CONCLUSION
Gelatinase plays an important role in the adaptive remondling of young rat condylar cartilage during functional mandibular advancement.
目的
研究功能性下颌前伸过程中年轻大鼠髁突软骨中明胶酶（基质金属蛋白酶-2、基质金属蛋白酶-9）表达的变化。
方法
将60只5周龄雄性SD大鼠分为实验组和对照组。实验组大鼠使用模拟功能性矫治器。分别在1、2、4周后处死动物。采用免疫组织化学法检测明胶酶的免疫反应性。
结果
在正常下颌髁突软骨中，基质金属蛋白酶-2的免疫反应性较强，基质金属蛋白酶-9的免疫反应性较弱。功能性下颌前伸后，基质金属蛋白酶-9的表达显著增加（P<0.01），但基质金属蛋白酶-2的免疫反应性无明显变化。
结论
明胶酶在功能性下颌前伸过程中年轻大鼠髁突软骨的适应性改建中起重要作用。
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