Huang San-Yuan, Lu Ru-Band, Ma Kuo-Hsing, Shy Mee-Jen, Lin Wei-Wen
Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Drug Alcohol Depend. 2008 Jan 1;92(1-3):20-6. doi: 10.1016/j.drugalcdep.2007.06.003. Epub 2007 Jul 13.
Several studies have suggested that the norepinephrine transporter (NET) may play an important role in the pathogenesis of alcohol dependence. Additional studies have shown that the polymorphisms of T-182C (rs2242446) and G1287A (rs5569) in NET gene (hSLC6A2) may affect the NET function. Therefore, in this study, we examined whether these hSLC6A2 gene polymorphisms are a susceptibility factor for alcohol dependence or its clinical subgroup(s). A total of 690 Han Chinese subjects (408 alcohol dependent patients and 282 controls) in Taiwan were recruited for this study. Individuals with alcohol dependence were classified into several clinical subgroups to reduce the clinical heterogeneity. All subjects were interviewed with identical methods, and the mental disorders were diagnosed according to DSM-IV criteria. The polymorphisms of T-182C and G1287A in hSLC6A2 gene were analyzed by using a standard method. No significant differences in genotype and allele frequencies of hSLC6A2 polymorphisms were found between controls and total alcohol dependence or between more homogeneous subgroups with alcohol dependence and controls. This study suggests that the polymorphisms of T-182C and G1287A in hSLC6A2 gene are not major risk factors in increasing susceptibility to either alcohol dependence or its clinical subtypes.
多项研究表明，去甲肾上腺素转运体（NET）可能在酒精依赖的发病机制中起重要作用。更多研究显示，NET基因（hSLC6A2）中T-182C（rs2242446）和G1287A（rs5569）的多态性可能会影响NET功能。因此，在本研究中，我们检测了这些hSLC6A2基因多态性是否是酒精依赖或其临床亚组的易感因素。本研究招募了台湾地区690名汉族受试者（408名酒精依赖患者和282名对照）。酒精依赖个体被分为几个临床亚组以减少临床异质性。所有受试者均采用相同方法进行访谈，并根据《精神疾病诊断与统计手册》第四版标准诊断精神障碍。采用标准方法分析hSLC6A2基因中T-182C和G1287A的多态性。在对照组与总的酒精依赖组之间，或在酒精依赖程度更一致的亚组与对照组之间，未发现hSLC6A2多态性的基因型和等位基因频率存在显著差异。本研究表明，hSLC6A2基因中T-182C和G1287A的多态性不是增加酒精依赖或其临床亚型易感性的主要危险因素。
