[糖皮质激素受体α和β在伴鼻息肉慢性鼻-鼻窦炎中的表达]

[Expression of glucocorticoid receptor alpha and beta in chronic rhinosinusitis with nasal polyp].

作者信息

Wang Ming-Ming, Zhang Hong-Ping, Wang Zhe, Chen Xue-Mei, Zhang Da-Liang

机构信息

Department of Otorhinolaryngology, Second Hospital of Shandong University, Jinan 250033, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Feb;42(2):143-6.

PMID:17633260

Abstract

OBJECTIVE

To detect the expression of glucocorticoid receptor (GR) alpha and beta in nasal polyps, and analyze the possible relationship between over-expression of GR beta and steroid insensitivity.

METHODS

The expression of GR alpha and GR beta was examined by immunohistochemical SP method in the specimens from 17 patients with recurring nasal polyp, 18 patients with chronic rhinosinusitis and nasal polyp (CRSwNP), and 12 patients with chronic rhinosinusitis without nasal polyp (CRSsNP) that did not recur during follow-up for 1.5 - 2 years.

RESULTS

The difference of numbers of GR alpha-positive cells (x +/- s) between groups with recurrent nasal polyp (20.2 +/- 6.9), CRSwNP (20.7 +/-7.2) , CRSsNP (16.9 +/- 7.2) and normal subjects (16.1 +/- 5.3) was not significant (P > 0.05). The numbers of GR beta-positive cells in recurring group (34.2 +/- 7.4) or CRSwNP (31.5 +/- 5.9) were higher than that in CRSsNP (19.8 +/- 7.8) and normal group (10.1 +/- 6.7) respectively (all P < 0.05). There was a trend toward higher level in recurring polyp compared with that of CRSwNP patients without recurrence in follow-up period, although this was not statistically different (P = 0.558). The difference of GR beta/GR alpha ratios (x +/- s) in recurring specimens (1.80 +/- 0.47) and CRSwNP group (1.65 +/- 0.49) was significant compared with normal group (0.77 +/- 0.66) respectively (P < 0.05), while there was no significance compared with CRSsNP (1.23 +/- 0.27, P > 0.05).

CONCLUSIONS

The high expression of GR beta in nasal polyp is related to the development of nasal polyp.

摘要

目的

检测糖皮质激素受体（GR）α和β在鼻息肉中的表达，并分析GRβ过表达与类固醇不敏感性之间的可能关系。

方法

采用免疫组织化学SP法检测17例复发性鼻息肉患者、18例慢性鼻窦炎伴鼻息肉（CRSwNP）患者及12例慢性鼻窦炎不伴鼻息肉（CRSsNP）患者（随访1.5 - 2年未复发）标本中GRα和GRβ的表达。

结果

复发性鼻息肉组（20.2±6.9）、CRSwNP组（20.7±7.2）、CRSsNP组（16.9±7.2）与正常对照组（16.1±5.3）GRα阳性细胞数差异无统计学意义（P＞0.05）。复发性鼻息肉组（34.2±7.4）和CRSwNP组（31.5±5.9）GRβ阳性细胞数分别高于CRSsNP组（19.8±7.8）和正常对照组（10.1±6.7）（均P＜0.05）。随访期内复发性鼻息肉患者GRβ阳性细胞数较未复发的CRSwNP患者有升高趋势，但差异无统计学意义（P = 0.558）。复发性标本（1.80±0.47）和CRSwNP组（1.65±0.49）GRβ/GRα比值与正常对照组（0.77±0.66）相比差异有统计学意义（P＜0.05），与CRSsNP组（1.23±0.27）相比差异无统计学意义（P＞0.05）。