Dorado P, Peñas-Lledó E M, González A P, Cáceres M C, Cobaleda J, Llerena A
Clinical Research Centre (CICAB), University Hospital, University of Extremadura Medical School, Servicio Extremeño de Salud, Badajoz, Spain.
Fundam Clin Pharmacol. 2007 Aug;21(4):451-3. doi: 10.1111/j.1472-8206.2007.00501.x.
In the present study, we aimed to analyze the potential relevance of the polymorphism in the promoter region of the serotonin transporter (SERT or 5-HTT) gene (5-HTTLPR) and the risk of suffering major depression (MDD) in a population of patients previously genotyped for CYP2C9. Seventy white European psychiatric outpatients suffering from MDD and a group of 142 healthy volunteers (HVs) were studied. The frequency of subjects carrying the 5-HTTLPR-S allele was higher (P < 0.05) among MDD than in HV. The odds ratio associated with 5-HTTLPR-S allele was 2.03 for the MDD patients in comparison with the HV group. Previously, we found in this population that the CYP2C93 allele frequency was higher among this population of MDD patients than in HV. The frequency of subjects with the combination 5-HTTLPR-S and CYP2C93 alleles was higher (P < 0.01, odds ratio 3.47) in MDD than in HV. The present findings provide preliminary evidence about the greater risk of suffering MDD for individuals carrying both 5-HTTLPR-S and CYP2C9*3 alleles.
在本研究中，我们旨在分析血清素转运体（SERT或5-HTT）基因启动子区域多态性（5-HTTLPR）与先前已进行CYP2C9基因分型的患者群体中患重度抑郁症（MDD）风险之间的潜在相关性。我们研究了70名患有MDD的欧洲白人精神科门诊患者以及一组142名健康志愿者（HV）。携带5-HTTLPR-S等位基因的MDD患者比例高于HV（P < 0.05）。与HV组相比，MDD患者中与5-HTTLPR-S等位基因相关的优势比为2.03。此前，我们在该群体中发现，MDD患者群体中CYP2C93等位基因频率高于HV。同时携带5-HTTLPR-S和CYP2C93等位基因的MDD患者比例高于HV（P < 0.01，优势比3.47）。本研究结果为同时携带5-HTTLPR-S和CYP2C9*3等位基因的个体患MDD风险更高提供了初步证据。
