Stratmann H
Department of Cardiology, St. Louis Veterans Administration Medical Center, St. Louis, Missouri.
Angiology. 1991 Dec;42(12):948-56. doi: 10.1177/000331979104201202.
Multiple measurements of pulmonary function were performed during exercise testing in 29 patients with coronary artery disease (CAD) before and after exercise training. Following training, significant increases in oxygen consumption (VO2), carbon dioxide production (VCO2), and peak flow at maximal exercise were seen as compared with pretraining values (p less than .01), but not in any other respiratory variables. Only the peak respiratory exchange ratio (RER) achieved during pretraining exercise testing and peak values of minute ventilation (VT), respiratory rate, and VCO2 during a posttraining exercise test showed significant correlations with the change in maximum VO2 following exercise training (p less than .05). Significant correlations were also found among VT, VCO2, and peak flow at peak exercise following exercise training and the change in exercise duration between pretraining and posttraining stress tests. Of 22 patients evaluated with thallium 201 scintigraphy during their pretraining exercise test, 11 developed ischemic ST depression or a reversible perfusion defect. No significant differences in pulmonary function measurements during exercise testing were seen between patients who developed ischemia and those who did not. However, the change in peak metabolic equivalents (METS) achieved between pretraining and posttraining exercise was significantly greater in patients who developed ischemia (.836 +/- 1.003 versus .091 +/- .481, p less than .05). These results indicate that exercise training in patients with CAD is not associated with significant changes in most measurements of pulmonary function and, with the exception of RER at peak exercise, pretraining measurements do no show a significant correlation with changes in exercise capacity.
对29例冠心病（CAD）患者在运动训练前后的运动试验期间进行了多次肺功能测量。训练后，与训练前的值相比，最大运动时的氧耗量（VO2）、二氧化碳生成量（VCO2）和峰值流量显著增加（p<0.01），但其他呼吸变量未见显著变化。仅训练前运动试验期间达到的峰值呼吸交换率（RER）以及训练后运动试验期间的分钟通气量（VT）、呼吸频率和VCO2的峰值与运动训练后最大VO2的变化呈显著相关（p<0.05）。训练后峰值运动时的VT、VCO2和峰值流量以及训练前和训练后应激试验之间运动持续时间的变化之间也发现了显著相关性。在22例在训练前运动试验期间接受铊201闪烁显像评估的患者中，11例出现了缺血性ST段压低或可逆性灌注缺损。出现缺血的患者和未出现缺血的患者在运动试验期间的肺功能测量结果无显著差异。然而，出现缺血的患者训练前和训练后运动时达到的峰值代谢当量（METS）的变化显著更大（0.836±1.003对0.091±0.481，p<0.05）。这些结果表明，CAD患者的运动训练与大多数肺功能测量的显著变化无关，除了峰值运动时的RER外，训练前测量结果与运动能力的变化无显著相关性。
