Bauman Jay, Eggleston Mark, Oquist Niki, Malinoski Frank
Scientific and Technical Evaluation of Pharmaceuticals, Inc., Raleigh, NC, USA.
South Med J. 2007 Jul;100(7):669-76. doi: 10.1097/SMJ.0b013e318048589e.
The aims of this study are to define the length of the respiratory syncytial virus (RSV) season throughout Florida and evaluate the American Academy of Pediatrics (AAP) guidelines on the administration of palivizumab in light of the Florida data.
We retrospectively analyzed four seasons of monthly RSV surveillance data housed on the Florida Department of Health website for regional trends in RSV outbreaks.
RSV circulated year round in Florida, with December being the peak month for RSV activity statewide. Regional virology data showed consistent patterns throughout the observation period, and all regions experienced widespread RSV activity for at least seven months of the year. The southeast region experienced the longest RSV seasons (10-12 mo), with year round outbreaks observed during 2000 to 2001 and 2001 to 2002.
Local RSV surveillance provides meaningful data to guide decisions on the administration of palivizumab. Reliance on current AAP guidelines for RSV prophylaxis would result in under-protection of at-risk children in all regions within the state of Florida.
本研究的目的是确定整个佛罗里达州呼吸道合胞病毒（RSV）流行季的时长，并根据佛罗里达州的数据评估美国儿科学会（AAP）关于使用帕利珠单抗的指南。
我们回顾性分析了佛罗里达州卫生部网站上四个季节的每月RSV监测数据，以了解RSV暴发的区域趋势。
RSV在佛罗里达州全年传播，12月是全州RSV活动的高峰月。区域病毒学数据在整个观察期内显示出一致的模式，并且所有地区一年中至少有七个月经历广泛的RSV活动。东南部地区的RSV流行季最长（10 - 12个月），在2000年至2001年以及2001年至2002年期间观察到全年暴发。
当地RSV监测提供了有意义的数据，以指导关于使用帕利珠单抗的决策。依赖当前AAP的RSV预防指南将导致佛罗里达州所有地区的高危儿童保护不足。
