盐酸多巴酚丁胺的体外和体内抗菌活性评估。
Evaluation of in vitro and in vivo antibacterial activity of dobutamine hydrochloride.
作者信息
Sarkar A, Kumar K A, Dutta N K, Chakraborty P, Dastidar S G
机构信息
Department of Pharmaceutical Technology, Jadavpur University, Kolkota - 700 032, India.
出版信息
Indian J Med Microbiol. 2003 Jul-Sep;21(3):172-8.
PURPOSE
To determine the in vitro and in vivo antibacterial activity of a cardiovascular drug dobutamine hydrochloride.
METHODS
The minimum inhibitory concentration (MIC) of dobutamine was determined both by agar and broth dilution methods against 331 strains of bacteria from three gram positive and 13 gram negative genera. The antibacterial action of dobutamine was further tested in animal models.
RESULTS
Dobutamine was seen to possess powerful inhibitory action (5-200mg/mL) against most test bacteria in in vitro studies. It was bacteriostatic in nature. In vivo studies showed that the drug offered significant protection (p< 0.001) to mice challenged with a virulent bacterium.
CONCLUSION
Dobutamine showed remarkable antibacterial property against several pathogenic bacteria. Its potential as an antibacterial agent may be confirmed after further pharmacological studies.
目的
确定心血管药物盐酸多巴酚丁胺的体外和体内抗菌活性。
方法
采用琼脂稀释法和肉汤稀释法测定多巴酚丁胺对来自3个革兰氏阳性菌属和13个革兰氏阴性菌属的331株细菌的最低抑菌浓度（MIC）。在动物模型中进一步测试多巴酚丁胺的抗菌作用。
结果
在体外研究中，多巴酚丁胺对大多数测试细菌具有强大的抑制作用（5-200mg/mL）。其本质上具有抑菌作用。体内研究表明，该药物对受到强毒细菌攻击的小鼠提供了显著的保护作用（p<0.001）。
结论
多巴酚丁胺对几种病原菌显示出显著的抗菌特性。其作为抗菌剂的潜力可能需要进一步的药理学研究来证实。
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