专家系统在进行临床药物试验中的价值。

The value of an expert system in performing clinical drug trials.

作者信息

Dassen W R, Mulleneers R, Frank H L

机构信息

Department of Cardiology, University of Limburg, Maastricht, The Netherlands.

出版信息

Comput Biol Med. 1991;21(4):193-8. doi: 10.1016/0010-4825(91)90001-p.

DOI:10.1016/0010-4825(91)90001-p

PMID:1764928

Abstract

An expert system has been designed to assist the cardiologist in determining whether patients can be included in clinical trials. This system contains knowledge on inclusion and exclusion criteria for six drug trials, and has been validated in 100 randomly selected patients. In 97 cases, the expert system and the cardiologist made an identical classification; in the remaining three cases, the patient was incorrectly classified by the physician. The system will also optimize the order in which questions are asked in order to minimize the time required to decide on inclusion or exclusion.

摘要

已设计出一个专家系统，以协助心脏病专家确定患者是否可纳入临床试验。该系统包含六项药物试验的纳入和排除标准知识，并已在100名随机挑选的患者中得到验证。在97例病例中，专家系统和心脏病专家做出了相同的分类；在其余三例中，医生对患者进行了错误分类。该系统还将优化提问顺序，以尽量减少决定纳入或排除所需的时间。