Barthell Elisabeth, Mylonas Ioannis, Shabani Naim, Kunze Susanne, Kuhn Christina, Jeschke Udo, Friese Klaus
First Department of Obstetrics and Gynecology, Ludwig Maximilians University Munich, Maistrasse 11, 80337 München, Germany.
Anticancer Res. 2007 Jul-Aug;27(4A):2035-9.
Cathepsin D (Cath-D), a lysosomal protease, is considered to be involved in the breakdown of the extracellular matrix during the process of tumour metastasis. Its expression in breast cancer in association with known factors of prognosis was investigated in this study.
120 breast cancer tumours were analysed immunohistochemically and evaluated with the immunoreactive score (IRS). Statistical evaluation was performed using the Mann-Whitney test (p < 0.05).
For nodal-positive tumors we found a statistically significant increase of Cath-D immunohistochemical reaction. Ductal carcinomas showed a significantly higher immunohistochemical reaction compared to lobular carcinomas. We found a non-significant increase from G1 to G2 and G1 to G3, and a non-significant increase of Cath-D expression of all receptor-positive over all receptor-negative tumours.
Cath-D expression was found to be associated with known prognostic factors. The clinical relevance of the observed difference depending on the histological type needs further investigation. Cath-D might be a useful marker to discriminate between ductal and lobular subtypes of breast cancer.
组织蛋白酶D（Cath-D）是一种溶酶体蛋白酶，被认为在肿瘤转移过程中参与细胞外基质的分解。本研究调查了其在乳腺癌中的表达与已知预后因素的关系。
对120例乳腺癌肿瘤进行免疫组织化学分析，并采用免疫反应评分（IRS）进行评估。使用Mann-Whitney检验进行统计学评估（p < 0.05）。
对于淋巴结阳性肿瘤，我们发现Cath-D免疫组化反应有统计学意义的增加。与小叶癌相比，导管癌显示出明显更高的免疫组化反应。我们发现从G1到G2以及从G1到G3有不显著的增加，并且所有受体阳性肿瘤的Cath-D表达相对于所有受体阴性肿瘤有不显著的增加。
发现Cath-D表达与已知预后因素相关。根据组织学类型观察到的差异的临床相关性需要进一步研究。Cath-D可能是区分乳腺癌导管和小叶亚型的有用标志物。
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