Li Xian-kai, Li Jue, Xing Yan, Buaijiaer Hasimu, Yu Jin-ming, Luo Ying-yi, Zheng Li-qiang, Hu Da-yi
Center of Heart, Lung and Blood Vessel Disease, Tongji University, Shanghai 200092, China.
Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):960-3.
To study the relationship between ankle-brachial index (ABI) and all cause mortality and cardiovascular disease mortality in men with several atherosclerotic risk factors.
1941 male patients with no less than two atherosclerotic risk factors, aged 67 (36 approximately 96), from 20 hospitals in Shanghai and Beijing, underwent examination of ABI and were followed up for 13.6 +/- 1.3 months to record the all cause mortality and cardiovascular disease (CVD) mortality.
The baseline examination showed that 467 patients were with the ABI <or= 0.9 and diagnosed as with peripheral arterial disease (PAD) and 1474 patients were found as with the normal ABI (between 0.91 and 1.40). The age of the PAD patients was 72 +/- 10 years, significantly older than that of those patients with normal ABI (66 +/- 12 years, P < 0.001). The rates of hypertension, diabetes mellitus, and smoking of the PAD patients were 77.0%, 46.3%, and 71.0% respectively, all significantly higher than those of the patients with normal ABI (68.5%, 32.5%, and 63.4% respectively, P < 0.01, P < 0.01. and P < 0.03). The all cause mortality and CVD mortality of the PAD patients were 15.4% and 5.1% respectively, both significantly higher than those of the patients with the ABI > 0.9 (7.7% and 1.8%, both P < 0.01). After adjusting other risk factors, the patients with 0.41 < ABI <or= 0.9 were more than 1.585 times likely to die than those with 1.0 < ABI <or= 1.4 (95% CI: 1.126 approximately 2.230). The patients with the ABI <or= 0.4 were more than 4.443 times likely to die of CVD than those with 1.0 < ABI <or= 1.4 (95% CI: 1.811 approximately 10.902). The RR for CVD death in the patients with 0.41 < ABI <or= 0.9 was 1.859 (95% CI: 1.091 approximately 3.166). The all cause survival rate and CVD survival rate of the PAD group were both significantly lower than those of the normal-ABI group (both P < 0.001).
Low ABI is an independent risk factor to all cause mortality and CVD mortality, especially to CVD mortality.
研究踝臂指数（ABI）与患有多种动脉粥样硬化危险因素男性的全因死亡率和心血管疾病死亡率之间的关系。
1941例来自上海和北京20家医院、年龄67岁（36至96岁）、患有不少于两种动脉粥样硬化危险因素的男性患者接受了ABI检查，并随访13.6±1.3个月以记录全因死亡率和心血管疾病（CVD）死亡率。
基线检查显示，467例患者ABI≤0.9，被诊断为外周动脉疾病（PAD），1474例患者ABI正常（0.91至1.40之间）。PAD患者年龄为72±10岁，显著高于ABI正常患者（66±12岁，P<0.001）。PAD患者的高血压、糖尿病和吸烟率分别为77.0%、46.3%和71.0%，均显著高于ABI正常患者（分别为68.5%、32.5%和63.4%，P<0.01、P<0.01和P<0.03）。PAD患者的全因死亡率和CVD死亡率分别为15.4%和5.1%，均显著高于ABI>0.9的患者（分别为7.7%和1.8%，均P<0.01）。调整其他危险因素后，0.41<ABI≤0.9的患者死亡可能性是1.0<ABI≤1.4患者的1.585倍以上（95%CI：1.126至2.230）。ABI≤0.4的患者死于CVD的可能性是1.0<ABI≤1.4患者的4.443倍以上（95%CI：1.811至10.902）。0.41<ABI≤0.9患者CVD死亡的RR为1.859（95%CI：1.091至3.166）。PAD组的全因生存率和CVD生存率均显著低于正常ABI组（均P<0.001）。
低ABI是全因死亡率和CVD死亡率的独立危险因素，尤其是CVD死亡率。
