血管紧张素转换酶基因插入/缺失多态性与过敏性接触性皮炎的关联。
Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with allergic contact dermatitis.
作者信息
Nacak Muradiye, Erbagci Zulal, Buyukafsar Kansu, Yurtsever Ahmet Sencer, Tiftik Rukiye Nalan
机构信息
Department of Pharmacology, Faculty of Medicine, Mersin University, Mersin, Turkey.
出版信息
Basic Clin Pharmacol Toxicol. 2007 Aug;101(2):101-3. doi: 10.1111/j.1742-7843.2007.00077.x.
Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present study was to investigate the possible association between allergic contact dermatitis and insertion/deletion polymorphism of the ACE gene. A total of 90 patients with allergic contact dermatitis and 160 control persons were enrolled in the present study. ACE I/D genotypes were determined by the polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control group (ACE II genotype 30.0% versus 17.5%, P = 0.022; ACE I allele 51.7% versus 39.4%, P = 0.008). Our data suggest that the ACE polymorphism could be a risk factor for patients with allergic contact dermatitis.
血管紧张素转换酶（ACE）在血压和炎症的生理调节中发挥着重要作用。人们对ACE基因的插入/缺失（I/D）多态性与心血管、脑血管、神经退行性和炎症性疾病的关系进行了研究。本研究的目的是探讨过敏性接触性皮炎与ACE基因插入/缺失多态性之间可能存在的关联。本研究共纳入了90例过敏性接触性皮炎患者和160名对照者。通过聚合酶链反应确定ACE I/D基因型。患者组中ACE I/D多态性的等位基因频率和基因型分布与对照组有显著差异（ACE II基因型为30.0%对17.5%，P = 0.022；ACE I等位基因为51.7%对39.4%，P = 0.008）。我们的数据表明，ACE多态性可能是过敏性接触性皮炎患者的一个危险因素。
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