影响HIV感染易感性和艾滋病进展的宿主因素。
Host factors influencing susceptibility to HIV infection and AIDS progression.
作者信息
Lama Juan, Planelles Vicente
机构信息
La Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California 92121, USA.
出版信息
Retrovirology. 2007 Jul 25;4:52. doi: 10.1186/1742-4690-4-52.
Transmission of HIV first results in an acute infection, followed by an apparently asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most patients progress into a generalized immune dysfunction that culminates in death. The length of the asymptomatic period varies, and in rare cases infected individuals never progress to AIDS. Other individuals whose behavioral traits put them at high-risk of HIV transmission, surprisingly appear resistant and never succumb to infection. These unique cases highlight the fact that susceptibility to HIV infection and progression to disease are complex traits modulated by environmental and genetic factors. Recent evidence has indicated that natural variations in host genes can influence the outcome of HIV infection and its transmission. In this review we summarize the available literature on the roles of cellular factors and their genetic variation in modulating HIV infection and disease progression.
艾滋病毒的传播首先会导致急性感染，随后是平均持续十年的明显无症状期。在没有抗逆转录病毒治疗的情况下，大多数患者会发展为全身性免疫功能障碍，最终导致死亡。无症状期的时长各不相同，在极少数情况下，受感染个体不会发展成艾滋病。其他一些因其行为特征而处于艾滋病毒传播高风险的个体，令人惊讶地表现出抵抗力，从未感染艾滋病毒。这些独特的案例凸显了一个事实，即对艾滋病毒感染的易感性以及疾病进展是由环境和遗传因素调节的复杂特征。最近的证据表明，宿主基因的自然变异会影响艾滋病毒感染及其传播的结果。在这篇综述中，我们总结了关于细胞因子及其基因变异在调节艾滋病毒感染和疾病进展中所起作用的现有文献。
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