肺炎支原体相关脑炎中的抗半乳糖脑苷脂检测
Anti-galactocerebroside testing in Mycoplasma pneumoniae-associated encephalitis.
作者信息
Christie Laura J, Honarmand Somayeh, Yagi Shigeo, Ruiz Sara, Glaser Carol A
机构信息
California Department of Health Services, Viral and Rickettsial Disease Laboratory, 850 Marina Bay Parkway, Richmond, CA 948040, USA.
出版信息
J Neuroimmunol. 2007 Sep;189(1-2):129-31. doi: 10.1016/j.jneuroim.2007.06.017. Epub 2007 Jul 24.
Mycoplasma pneumoniae (Mp) is the most frequently identified pathogen in the California Encephalitis Project, but the role and mechanism of Mp is unclear. Since auto-antibodies to anti-galactocerebroside (anti-GalC) have been reported in patients with evidence of acute Mp infection of the central nervous system (CNS), serum and cerebrospinal fluid (CSF) samples from 26 patients with evidence of Mp were tested for anti-GalC antibodies. Anti-GalC antibody was found in the CSF of only eight (31%) of 21 Mp patients indicating that CSF anti-GalC antibody is not a specific marker for Mp CNS disease.
肺炎支原体（Mp）是加州脑炎项目中最常鉴定出的病原体，但Mp的作用和机制尚不清楚。由于在有中枢神经系统（CNS）急性Mp感染证据的患者中已报告存在抗半乳糖脑苷脂自身抗体（抗-GalC），因此对26例有Mp感染证据患者的血清和脑脊液（CSF）样本进行了抗-GalC抗体检测。在21例Mp患者中，仅8例（31%）的脑脊液中发现了抗-GalC抗体，这表明脑脊液抗-GalC抗体不是Mp中枢神经系统疾病的特异性标志物。
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