Wilson Steven E, Chaurasia Shyam S, Medeiros Fabricio W
The Cole Eye Institute, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Exp Eye Res. 2007 Sep;85(3):305-11. doi: 10.1016/j.exer.2007.06.009. Epub 2007 Jun 21.
Stromal keratocyte apoptosis has been well-characterized as an early initiating event of the corneal wound healing response, triggering subsequent cellular processes that include bone marrow-derived cell infiltration, proliferation and migration of residual keratocyte cells, and, in some circumstances, generation of myofibroblast cells. Recent studies, however, have suggested a more general role for apoptosis in the overall stromal wound healing response that includes modulation and termination functions. This review article highlights, and ties together, recent studies that have demonstrated the important role apoptosis likely plays in weeks to months following an initial insult to the cornea-depending on the type and extent of corneal injury.
基质角膜细胞凋亡已被充分表征为角膜伤口愈合反应的早期起始事件，触发随后的细胞过程，包括骨髓来源细胞浸润、残余角膜细胞的增殖和迁移，以及在某些情况下肌成纤维细胞的生成。然而，最近的研究表明，凋亡在整个基质伤口愈合反应中具有更广泛的作用，包括调节和终止功能。这篇综述文章重点介绍并整合了最近的研究，这些研究表明，根据角膜损伤的类型和程度，凋亡可能在角膜初次损伤后的数周乃至数月内发挥重要作用。
