Brown George W, Craig Tom K J, Harris Tirril O, Handley Rachel V, Harvey Anna L
Department of Social Psychiatry Group, King's College London, St Thomas' Hospital Campus, Lambeth Palace Road, London, SE1 7EH, UK.
J Affect Disord. 2007 Nov;103(1-3):217-24. doi: 10.1016/j.jad.2007.06.003. Epub 2007 Jul 25.
A previous paper, using data collected retrospectively from sister pairs, reported substantial associations of adult depressive episodes lasting at least 12 months with childhood maltreatment [Brown, G.W., Craig, T.K.J., Harris, T.O. Handley, R.V. & Harvey, A.L. 2007a-this issue. Development of a retrospective interview measure of parental maltreatment using the Childhood Experience of Care & Abuse (CECA) instrument - a life-course study of adult chronic depression - 1. J. Affect. Disord. doi:10.1016/j.jad.2007.05.022]. Risk was far less when depressive episodes of any duration were considered. This paper considers how much scientific weight can be placed on these findings in the light of doubt often expressed about retrospective collection of childhood and adult data.
The retrospectively gathered material was obtained from adult sister pairs within 5 years of age, comprising a high-risk series (n = 118) where the first sister was selected as likely to have experienced childhood abuse or neglect, and a comparison series (n = 80) where she was selected at random. Current age ranged between early 20s and 50s. Data was collected by semi-structured interviews, using investigator-based ratings covering a wide range of parental behaviour and childhood behaviour.
A series of analyses failed to reveal evidence of significant bias in the collection of material about adult depression or parental maltreatment. There was, however, some evidence of under reporting.
Conclusions from such analyses can only be judged in terms of degree of plausibility.
Nothing emerged to suggest the presence of significant bias in the aetiological findings of our earlier paper. There is evidence of some underreporting of both early adverse experience and adult depressive episodes, but this is unlikely to threaten the conclusions drawn about the link of parental maltreatment with adult chronic depressive episodes.
之前有一篇论文,利用从姐妹对中回顾性收集的数据,报告了持续至少12个月的成人抑郁发作与童年期虐待之间存在显著关联[布朗,G.W.,克雷格,T.K.J.,哈里斯,T.O.,汉德利,R.V.及哈维,A.L. 2007a - 本期。使用关爱与虐待儿童经历(CECA)工具开发一种回顾性访谈测量方法——成人慢性抑郁症的生命历程研究——1。《情感障碍杂志》。doi:10.1016/j.jad.2007.05.022]。若考虑任何持续时间的抑郁发作,风险则要低得多。鉴于人们常常对童年和成人数据的回顾性收集表示怀疑,本文探讨了这些研究结果有多大的科学可信度。
回顾性收集的材料来自年龄相差5岁以内的成年姐妹对,包括一个高风险组(n = 118),其中第一个姐妹被选为可能经历过童年期虐待或忽视的对象,以及一个对照组(n = 80),其中第一个姐妹是随机选取的。当前年龄在20岁出头到50多岁之间。数据通过半结构化访谈收集,采用基于研究者的评分,涵盖广泛的父母行为和童年行为。
一系列分析未能揭示在收集有关成人抑郁症或父母虐待的材料时存在显著偏差的证据。然而,有一些证据表明存在报告不足的情况。
此类分析得出的结论只能根据合理性程度来判断。
没有任何迹象表明我们早期论文的病因学研究结果存在显著偏差。有证据表明早期不良经历和成人抑郁发作都存在一些报告不足的情况,但这不大可能威胁到关于父母虐待与成人慢性抑郁发作之间联系所得出的结论。