与血清β-人绒毛膜促性腺激素测量相比，半定量尿液妊娠试验的准确性：药物流产后持续妊娠的一种可能筛查工具。
Accuracy of a semi-quantitative urine pregnancy test compared to serum beta-hCG measurement: a possible screening tool for ongoing pregnancy after medication abortion.
作者信息
Grossman Daniel, Berdichevsky Karla, Larrea Fernando, Beltran Jorge
机构信息
Ibis Reproductive Health, c/o Department of Obstetrics and Gynecology, San Francisco General Hospital, San Francisco, CA 94110, USA.
出版信息
Contraception. 2007 Aug;76(2):101-4. doi: 10.1016/j.contraception.2007.04.008. Epub 2007 Jun 18.
PURPOSE
Medication abortion protocols commonly rely on ultrasound or serum hCG measurement to confirm completion. In order to explore the use of a urine-based test to screen for ongoing pregnancy, we compared the diagnostic accuracy of a recently developed semi-quantitative urine pregnancy test to serum beta-hCG testing.
METHODS
We evaluated the urine test with 97 women in early pregnancy at a hospital and private clinic in Mexico City. The results of the urine test (hCG level > or <1000 IU/L) were correlated with those of a serum quantitative beta-hCG immunoradiometric assay.
RESULTS
The sensitivity of the urine test to identify individuals with a serum beta-hCG level >1000 IU/L was 88.6% (95% CI 74.6- 95.7%), and its specificity was 71.7% (95% CI 57.4-82.8%).
CONCLUSION
The reasonably high sensitivity of this urine test suggests it might be useful as a screening test to detect ongoing pregnancy after medication abortion. Future research should evaluate its utility in clinical follow-up protocols.
目的
药物流产方案通常依靠超声检查或血清人绒毛膜促性腺激素（hCG）检测来确认流产是否完成。为了探索使用基于尿液的检测方法来筛查持续性妊娠，我们比较了一种新开发的半定量尿液妊娠试验与血清β-hCG检测的诊断准确性。
方法
我们在墨西哥城的一家医院和私人诊所对97名早期妊娠女性进行了尿液检测评估。尿液检测结果（hCG水平>或<1000 IU/L）与血清定量β-hCG免疫放射分析结果相关。
结果
尿液检测识别血清β-hCG水平>1000 IU/L个体的灵敏度为88.6%（95%置信区间74.6 - 95.7%），特异性为71.7%（95%置信区间57.4 - 82.8%）。
结论
这种尿液检测具有相当高的灵敏度，表明它可能作为药物流产后检测持续性妊娠的筛查试验有用。未来的研究应评估其在临床随访方案中的效用。
Zotero 插件