打结：套索肽的形成

Tying the knot: making of lasso peptides.

作者信息

Bierbaum Gabriele, Jansen Andrea

机构信息

Institute for Medical Microbiology, Immunology and Parasitology, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany.

出版信息

Chem Biol. 2007 Jul;14(7):734-5. doi: 10.1016/j.chembiol.2007.07.001.

DOI:10.1016/j.chembiol.2007.07.001

PMID:17656308

Abstract

In this issue of Chemistry & Biology, Duquesne and colleagues [1] describe the biosynthetic machinery of microcin J25, an antibacterial peptide that adopts an exceptional three-dimensional structure resembling a knot. The dedicated enzymes, McjB and McjC, were identified and employed to produce this modification in vitro.

摘要

在本期《化学生物学》中，杜肯及其同事 [1] 描述了微小菌素J25的生物合成机制，微小菌素J25是一种抗菌肽，具有异常的三维结构，类似一个结。他们鉴定出了专门的酶McjB和McjC，并利用它们在体外进行这种修饰。