结直肠癌发生：癌症的路线图
Colorectal carcinogenesis: road maps to cancer.
作者信息
Worthley Daniel-L, Whitehall Vicki-L, Spring Kevin-J, Leggett Barbara-A
机构信息
Conjoint Gastroenterology Laboratory, The Queensland Institute of Medical Research, the Bancroft Centre, rm H07, PO Royal Brisbane Hospital, Herston, QLD 4029, Australia.
出版信息
World J Gastroenterol. 2007 Jul 28;13(28):3784-91. doi: 10.3748/wjg.v13.i28.3784.
Abstract
This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.
摘要
本综述探讨了促进结直肠癌发生发展过程中病理进展的主要遗传和表观遗传事件。本文讨论了将结直肠肿瘤分为抑制型、突变型和甲基化型途径的分子和病理基础。这些不同的基因组不稳定机制与特定的癌症特征相关，并可能为未来更有效的预防和监测策略提供机会。这是关于结直肠癌重要和发展中方面的五个主题系列综述中的第一篇。
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