烯丙醇的化学酶促动态动力学拆分：一条合成乙酰基偶姻酯的高对映选择性路线。

Chemoenzymatic dynamic kinetic resolution of allylic alcohols: a highly enantioselective route to acyloin acetates.

作者信息

Bogár Krisztián, Vidal Pilar Hoyos, León Andrés R Alcántara, Bäckvall Jan-E

机构信息

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.

出版信息

Org Lett. 2007 Aug 16;9(17):3401-4. doi: 10.1021/ol071395v. Epub 2007 Jul 21.

DOI:10.1021/ol071395v

PMID:17658843

Abstract

Dynamic kinetic resolution (DKR) of a series of sterically hindered allylic alcohols has been conducted with Candida antarctica lipase B (CALB) and ruthenium catalyst 1. The optically pure allylic acetates obtained were subjected to oxidative cleavage to give the corresponding acylated acyloins in high yields without loss of chiral information.

摘要

利用南极假丝酵母脂肪酶B（CALB）和钌催化剂1对一系列空间位阻烯丙醇进行了动态动力学拆分（DKR）。所得到的光学纯烯丙基乙酸酯经过氧化裂解，以高收率得到相应的酰化偶姻，且手性信息无损失。